abstract：:Circadian clocks regulate most aspects of physiology and metabolism. Genome-wide approaches have uncovered widespread circadian rhythms in the transcriptome, cistrome, and epigenome of mice, and now two proteomics studies in this issue (Robles et al., 2016; Wang et al., 2016) reveal extensive circadian regulation of t...

journal_title：Cell metabolism

authors： Takahashi JS

更新日期：2017-01-10 00:00:00

abstract：:Metformin use is associated with reduced cancer mortality, but how metformin impacts cancer outcomes is controversial. Although metformin can act on cells autonomously to inhibit tumor growth, the doses of metformin that inhibit proliferation in tissue culture are much higher than what has been described in vivo. Here...

journal_title：Cell metabolism

authors： Gui DY,Sullivan LB,Luengo A,Hosios AM,Bush LN,Gitego N,Davidson SM,Freinkman E,Thomas CJ,Vander Heiden MG

更新日期：2016-11-08 00:00:00

abstract：:"Beige" adipocytes reside in white adipose tissue (WAT) and dissipate energy as heat. Several studies have shown that cold temperature can activate pro-opiomelanocortin-expressing (POMC) neurons and increase sympathetic neuronal tone to regulate WAT beiging. WAT, however, is traditionally known to be sparsely innervat...

journal_title：Cell metabolism

authors： Zhu Y,Gao Y,Tao C,Shao M,Zhao S,Huang W,Yao T,Johnson JA,Liu T,Cypess AM,Gupta O,Holland WL,Gupta RK,Spray DC,Tanowitz HB,Cao L,Lynes MD,Tseng YH,Elmquist JK,Williams KW,Lin HV,Scherer PE

更新日期：2016-09-13 00:00:00

abstract：:The circadian clock is a ubiquitous timekeeping system that organizes the behavior and physiology of organisms over the day and night. Current models rely on transcriptional networks that coordinate circadian gene expression of thousands of transcripts. However, recent studies have uncovered phylogenetically conserved...

journal_title：Cell metabolism

authors： Rey G,Valekunja UK,Feeney KA,Wulund L,Milev NB,Stangherlin A,Ansel-Bollepalli L,Velagapudi V,O'Neill JS,Reddy AB

更新日期：2016-09-13 00:00:00

abstract：:Human brown adipose tissue (BAT) presence, metabolic activity, and estimated mass are typically measured by imaging [18F]fluorodeoxyglucose (FDG) uptake in response to cold exposure in regions of the body expected to contain BAT, using positron emission tomography combined with X-ray computed tomography (FDG-PET/CT). ...

journal_title：Cell metabolism

authors： Chen KY,Cypess AM,Laughlin MR,Haft CR,Hu HH,Bredella MA,Enerbäck S,Kinahan PE,Lichtenbelt Wv,Lin FI,Sunderland JJ,Virtanen KA,Wahl RL

更新日期：2016-08-09 00:00:00

abstract：:Non-nutritive sweeteners like sucralose are consumed by billions of people. While animal and human studies have demonstrated a link between synthetic sweetener consumption and metabolic dysregulation, the mechanisms responsible remain unknown. Here we use a diet supplemented with sucralose to investigate the long-term...

journal_title：Cell metabolism

authors： Wang QP,Lin YQ,Zhang L,Wilson YA,Oyston LJ,Cotterell J,Qi Y,Khuong TM,Bakhshi N,Planchenault Y,Browman DT,Lau MT,Cole TA,Wong AC,Simpson SJ,Cole AR,Penninger JM,Herzog H,Neely GG

更新日期：2016-07-12 00:00:00

abstract：:The genetic mechanisms mediating longevity and maximum lifespan of the human species are likely different than those explaining differences in life expectancy and healthspan across individuals. Both of these perspectives are important and can be separated and explored using genomic data. ...

journal_title：Cell metabolism

authors： Telenti A,Perkins BA,Venter JC

更新日期：2016-06-14 00:00:00

abstract：:Mutations resulting in reduced signaling of the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis are associated with increased life- and healthspan across model organisms. Similar findings have been noted in human cohorts with functional mutations in the somatotropic axis, suggesting that this pathway may a...

journal_title：Cell metabolism

authors： Milman S,Huffman DM,Barzilai N

更新日期：2016-06-14 00:00:00

abstract：:Cells can enter quiescent states in which cell cycling and growth are suspended. We find that during a long developmental arrest (quiescence) induced by starvation, newly hatched C. elegans acquire features associated with impaired proteostasis and aging: mitochondrial fission, ROS production, protein aggregation, dec...

journal_title：Cell metabolism

authors： Roux AE,Langhans K,Huynh W,Kenyon C

更新日期：2016-06-14 00:00:00

abstract：:Signaling by the corticotropin-releasing factor receptor type 1 (CRFR1) plays an important role in mediating the autonomic response to stressful challenges. Multiple hypothalamic nuclei regulate sympathetic outflow. Although CRFR1 is highly expressed in the arcuate nucleus (Arc) of the hypothalamus, the identity of th...

journal_title：Cell metabolism

authors： Kuperman Y,Weiss M,Dine J,Staikin K,Golani O,Ramot A,Nahum T,Kühne C,Shemesh Y,Wurst W,Harmelin A,Deussing JM,Eder M,Chen A

更新日期：2016-06-14 00:00:00

abstract：:Mammary epithelial cells transition between periods of proliferation and quiescence during development, menstrual cycles, and pregnancy, and as a result of oncogenic transformation. Utilizing an organotypic 3D tissue culture model coupled with quantitative metabolomics and proteomics, we identified significant differe...

journal_title：Cell metabolism

authors： Coloff JL,Murphy JP,Braun CR,Harris IS,Shelton LM,Kami K,Gygi SP,Selfors LM,Brugge JS

更新日期：2016-05-10 00:00:00

abstract：:Glucose and hormone responsiveness of pancreatic β cells is acquired during postnatal maturation and is critical for appropriate insulin secretion. In a recent issue of Cell Metabolism, Yoshihara et al. (2016) report that estrogen-related receptor γ (ERRγ) promotes functional maturation of both mouse neonatal β cells ...

journal_title：Cell metabolism

authors： Shirakawa J,Kulkarni RN

更新日期：2016-05-10 00:00:00

abstract：:High sodium intake is a major risk factor for developing hypertension in diabetes. Promotion of sodium excretion reduces cardiometabolic lesions in diabetes. However, the interaction between sodium intake and glucose homeostasis remains elusive. Here, we report that high sodium intake remarkably increased natriuresis ...

journal_title：Cell metabolism

authors： Zhao Y,Gao P,Sun F,Li Q,Chen J,Yu H,Li L,Wei X,He H,Lu Z,Wei X,Wang B,Cui Y,Xiong S,Shang Q,Xu A,Huang Y,Liu D,Zhu Z

更新日期：2016-04-12 00:00:00

abstract：:Impaired angiogenesis has been implicated in adipose tissue dysfunction and the development of obesity and associated metabolic disorders. Here, we report the unexpected finding that vascular endothelial growth factor B (VEGFB) gene transduction into mice inhibits obesity-associated inflammation and improves metabolic...

journal_title：Cell metabolism

authors： Robciuc MR,Kivelä R,Williams IM,de Boer JF,van Dijk TH,Elamaa H,Tigistu-Sahle F,Molotkov D,Leppänen VM,Käkelä R,Eklund L,Wasserman DH,Groen AK,Alitalo K

更新日期：2016-04-12 00:00:00

abstract：:Nuclear receptors (NRs) are key regulators of gene expression and physiology. Nearly half of all human NRs lack endogenous ligands including estrogen-related receptor α (ERRα). ERRα has important roles in cancer, metabolism, and skeletal homeostasis. Affinity chromatography of tissue lipidomes with the ERRα ligand-bin...

journal_title：Cell metabolism

authors： Wei W,Schwaid AG,Wang X,Wang X,Chen S,Chu Q,Saghatelian A,Wan Y

更新日期：2016-03-08 00:00:00

abstract：:Glucagon drives hepatic gluconeogenesis and maintains blood glucose levels during fasting. The mechanism that attenuates glucagon action following refeeding is not understood. The present study demonstrates an increase in perivenous liver hypoxia immediately after feeding, which stabilizes hypoxia-inducible factor 2α ...

journal_title：Cell metabolism

authors： Ramakrishnan SK,Zhang H,Takahashi S,Centofanti B,Periyasamy S,Weisz K,Chen Z,Uhler MD,Rui L,Gonzalez FJ,Shah YM

更新日期：2016-03-08 00:00:00

abstract：:The mechanistic target of rapamycin complex 1 (mTORC1) coordinates nutrient availability with cell growth. Recent reports by Sabatini and coworkers (Saxton et al., 2016; Wolfson et al., 2016) characterize a cytoplasmic amino acid receptor that couples the binding of leucine to the activation of mTORC1. ...

journal_title：Cell metabolism

authors： Abraham RT

更新日期：2016-03-08 00:00:00

abstract：:Obesity is a heritable disorder, with children of obese fathers at higher risk of developing obesity. Environmental factors epigenetically influence somatic tissues, but the contribution of these factors to the establishment of epigenetic patterns in human gametes is unknown. Here, we hypothesized that weight loss rem...

journal_title：Cell metabolism

authors： Donkin I,Versteyhe S,Ingerslev LR,Qian K,Mechta M,Nordkap L,Mortensen B,Appel EV,Jørgensen N,Kristiansen VB,Hansen T,Workman CT,Zierath JR,Barrès R

更新日期：2016-02-09 00:00:00

abstract：:Advances in neuro-technology for mapping, manipulating, and monitoring molecularly defined cell types are rapidly advancing insight into neural circuits that regulate appetite. Here, we review these important tools and their applications in circuits that control food seeking and consumption. Technical capabilities pro...

journal_title：Cell metabolism

authors： Sternson SM,Atasoy D,Betley JN,Henry FE,Xu S

更新日期：2016-02-09 00:00:00

abstract：:Intestinal sugar sensing has an appetite-stimulating action that enhances preferences for sweets. Han et al. (2016) report that duodenal-jejunal bypass surgery reduces sweet appetite by reducing sugar-induced dopamine release in the dorsal striatum. ...

journal_title：Cell metabolism

authors： Sclafani A

更新日期：2016-01-12 00:00:00

abstract：:VEGF (vascular endothelial growth factor) signaling inhibitors are widely used in different cancer types; however, patient selection remains a challenge. Analyses of samples from a phase III clinical trial in metastatic colorectal cancer testing chemotherapy versus chemotherapy with the small molecule VEGF receptors i...

journal_title：Cell metabolism

authors： Pommier AJ,Farren M,Patel B,Wappett M,Michopoulos F,Smith NR,Kendrew J,Frith J,Huby R,Eberlein C,Campbell H,Womack C,Smith PD,Robertson J,Morgan S,Critchlow SE,Barry ST

更新日期：2016-01-12 00:00:00

abstract：:The essential role of the brain in maintaining energy homeostasis has motivated the drive to define the neural circuitry that integrates external and internal stimuli to enact appropriate and consequential metabolic and behavioral responses. The hypothalamus has received significant attention in this regard given its ...

journal_title：Cell metabolism

authors： Waterson MJ,Horvath TL

更新日期：2015-12-01 00:00:00

abstract：:The "Rosies" of Cell Metabolism are back for the third part of the "Women in Metabolism" 2015 series. We are closing our anniversary celebrations with 14 inspiring and engaging new stories from women scientists in the metabolism field. A round of applause to all who contributed and supported this project! ...

journal_title：Cell metabolism

authors： Ashcroft F,Pearce E,Partridge L,Suomalainen A,Brunet A,Schulze A,Tseng YH,Sethi JK,Reue K,Kingwell B,McNally E,Cnop M,Hevener AL,Diano S

更新日期：2015-12-01 00:00:00

abstract：:Fat and muscle lipolysis involves functional interactions of adipose triglyceride lipase (ATGL), α-β hydrolase domain-containing protein 5 (ABHD5), and tissue-specific perilipins 1 and 5 (PLIN1 and PLIN5). ABHD5 potently activates ATGL, but this lipase-promoting activity is suppressed when ABHD5 is bound to PLIN prote...

journal_title：Cell metabolism

authors： Sanders MA,Madoux F,Mladenovic L,Zhang H,Ye X,Angrish M,Mottillo EP,Caruso JA,Halvorsen G,Roush WR,Chase P,Hodder P,Granneman JG

更新日期：2015-11-03 00:00:00

abstract：:Aging is driven by changes of the epigenetic state that are only partially understood. We performed a comprehensive epigenomic analysis of the pancreatic β cell, key player in glucose homeostasis, in adolescent and very old mice. We observe a global methylation drift resulting in an overall more leveled methylome in o...

journal_title：Cell metabolism

authors： Avrahami D,Li C,Zhang J,Schug J,Avrahami R,Rao S,Stadler MB,Burger L,Schübeler D,Glaser B,Kaestner KH

更新日期：2015-10-06 00:00:00

abstract：:While mesenchymal stem cells (MSCs) are rapidly cleared from the body following systemic transplantation, their therapeutic benefits typically persist. In this issue, Liu et al. (2015) reveal that the ability of transplanted MSCs to alleviate osteoporosis in systemic lupus erythematosus is maintained through epigeneti...

journal_title：Cell metabolism

authors： Ng KS,Kuncewicz TM,Karp JM

更新日期：2015-10-06 00:00:00

abstract：:Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that integrate energy demand as well as the reinforcing and rewarding aspects of food. Understanding the net contribution of homeostatic and reward-driven feeding has become critical because of the ubiquitous source of energy-dense ...

journal_title：Cell metabolism

authors： Denis RG,Joly-Amado A,Webber E,Langlet F,Schaeffer M,Padilla SL,Cansell C,Dehouck B,Castel J,Delbès AS,Martinez S,Lacombe A,Rouch C,Kassis N,Fehrentz JA,Martinez J,Verdié P,Hnasko TS,Palmiter RD,Krashes MJ,Güler A

更新日期：2015-10-06 00:00:00

abstract：:Mitochondria undergo architectural/functional changes in response to metabolic inputs. How this process is regulated in physiological feeding/fasting states remains unclear. Here we show that mitochondrial dynamics (notably fission and mitophagy) and biogenesis are transcriptional targets of the circadian regulator Bm...

journal_title：Cell metabolism

authors： Jacobi D,Liu S,Burkewitz K,Kory N,Knudsen NH,Alexander RK,Unluturk U,Li X,Kong X,Hyde AL,Gangl MR,Mair WB,Lee CH

更新日期：2015-10-06 00:00:00

abstract：:The ability of hormones such as insulin, leptin, and cholecystokinin to alter food intake is influenced by intricate interactions between homeostatic and non-homeostatic factors. Consequently, when administered exogenously, the likelihood of these hormones influencing food intake is probabilistic, leading to difficult...

journal_title：Cell metabolism

authors： Woods SC,Begg DP

更新日期：2015-09-01 00:00:00

abstract：:Sphingolipids have garnered attention for their role in insulin resistance and lipotoxic cell death. We have developed transgenic mice inducibly expressing acid ceramidase that display a reduction in ceramides in adult mouse tissues. Hepatic overexpression of acid ceramidase prevents hepatic steatosis and prompts impr...

journal_title：Cell metabolism

authors： Xia JY,Holland WL,Kusminski CM,Sun K,Sharma AX,Pearson MJ,Sifuentes AJ,McDonald JG,Gordillo R,Scherer PE

更新日期：2015-08-04 00:00:00

abstract：:Type 1 diabetes is an autoimmune disease that manifests as impaired insulin secretion, with compounding complications over time. Bhatt et al. (2015) investigate protective mechanisms in survivors of type 1 diabetes by using induced pluripotent stem cells as genetic models, uncovering novel interactions between microRN...

journal_title：Cell metabolism

authors： Warren CR,Cowan CA

更新日期：2015-08-04 00:00:00

abstract：:The past 25 years have witnessed major advances in our knowledge of how exercise activates cellular, molecular, and biochemical pathways with regulatory roles in training response adaptation, and how muscle "cross-talk" with other organs is a mechanism by which physical activity exerts its beneficial effects on "whole...

journal_title：Cell metabolism

authors： Hawley JA,Maughan RJ,Hargreaves M

更新日期：2015-07-07 00:00:00

abstract：:In obesity, insulin resistance is linked to inflammation in several tissues. Although the gut is a very large lymphoid tissue, inflammation in the absorptive small intestine, the jejunum, where insulin regulates lipid and sugar absorption is unknown. We analyzed jejunal samples of 185 obese subjects stratified in thre...

journal_title：Cell metabolism

authors： Monteiro-Sepulveda M,Touch S,Mendes-Sá C,André S,Poitou C,Allatif O,Cotillard A,Fohrer-Ting H,Hubert EL,Remark R,Genser L,Tordjman J,Garbin K,Osinski C,Sautès-Fridman C,Leturque A,Clément K,Brot-Laroche E

更新日期：2015-07-07 00:00:00

abstract：:Mitochondrial dysfunction is associated with skeletal muscle pathology, including cachexia, sarcopenia, and the muscular dystrophies. ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes mitochondria-derived citrate into oxaloacetate and acetyl-CoA. Here we report that activation of ACL in skeletal muscle resu...

journal_title：Cell metabolism

authors： Das S,Morvan F,Jourde B,Meier V,Kahle P,Brebbia P,Toussaint G,Glass DJ,Fornaro M

更新日期：2015-06-02 00:00:00

abstract：:Nicotinamide phosphoribosyltransferase (NAMPT), the key NAD(+) biosynthetic enzyme, has two different forms, intra- and extracellular (iNAMPT and eNAMPT), in mammals. However, the significance of eNAMPT secretion remains unclear. Here we demonstrate that deacetylation of iNAMPT by the mammalian NAD(+)-dependent deacet...

journal_title：Cell metabolism

authors： Yoon MJ,Yoshida M,Johnson S,Takikawa A,Usui I,Tobe K,Nakagawa T,Yoshino J,Imai S

更新日期：2015-05-05 00:00:00

abstract：:Asymmetric distribution of damaged cellular constituents may occur during mitosis, resulting in more and less pristine daughter cell pairs. In Science, Katajisto et al., (2015) report that mammary stem-like cells (SLCs) unequally apportion older mitochondria to post-division daughter cells, with the daughter containin...

journal_title：Cell metabolism

authors： Teitell MA

更新日期：2015-05-05 00:00:00

abstract：:The mitochondrial contact site and cristae organizing system (MICOS) is a conserved multi-subunit complex crucial for maintaining the characteristic architecture of mitochondria. Studies with deletion mutants identified Mic10 and Mic60 as core subunits of MICOS. Mic60 has been studied in detail; however, topogenesis a...

journal_title：Cell metabolism

authors： Bohnert M,Zerbes RM,Davies KM,Mühleip AW,Rampelt H,Horvath SE,Boenke T,Kram A,Perschil I,Veenhuis M,Kühlbrandt W,van der Klei IJ,Pfanner N,van der Laan M

更新日期：2015-05-05 00:00:00

abstract：:Obesity-related morbidity and mortality are related to fat accumulation and fat distribution in humans. Two large-scale meta-analyses recently published in Nature by Shungin et al. (2015) and Locke et al. (2015) report novel genetic associations for central and overall obesity; these greatly advance our understanding ...

journal_title：Cell metabolism

authors： Fu J,Hofker M,Wijmenga C

更新日期：2015-04-07 00:00:00

abstract：:Although variants in the IGF2BP2/IMP2 gene confer risk for type 2 diabetes, IMP2, an RNA binding protein, is not known to regulate metabolism. Imp2(-/-) mice gain less lean mass after weaning and have increased lifespan. Imp2(-/-) mice are highly resistant to diet-induced obesity and fatty liver and display superior g...

journal_title：Cell metabolism

authors： Dai N,Zhao L,Wrighting D,Krämer D,Majithia A,Wang Y,Cracan V,Borges-Rivera D,Mootha VK,Nahrendorf M,Thorburn DR,Minichiello L,Altshuler D,Avruch J

更新日期：2015-04-07 00:00:00

abstract：:Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their pluripotent state. In this issue, Moussaieff et al. (2015) find that ESCs utilize glycolysis to fuel high rates of cytosolic acetyl-CoA synthesis to maintain the histone acetylation required for pluripotency. ...

journal_title：Cell metabolism

authors： Shyh-Chang N,Daley GQ

更新日期：2015-03-03 00:00:00